淺沼 広子

ASANUMA Hiroko

所属/職位 臨床検査学科/教授
学位・資格等 医学博士(札幌医科大学)  
臨床検査技師        
認定病理検査技師 
細胞検査士
国際細胞検査士
認定がんゲノム医療コーティネーター
ISO16189内部品質監査員資格取得
e-mail hrk-asanuma@jhu.ac.jp
主な担当科目 解剖学
臨床検査入門
解剖学演習
組織細胞学実習
病理検査学実習
細胞検査学実習
症例細胞検査学
遺伝子学実習
専門検査技師総論
臨床検査総合実習
臨床検査総論演習
臨床血液学実習I
卒業研究
所属学会 日本癌学会
日本病理学会
日本臨床細胞学会
日本臨床衛生検査学会

(委員歴)
2003年4月-2021年3月 北海道細胞検査士会 学術委員 
2004年4月-現在     札幌臨床検査技師会データ統一化プロジェクト委員 
2004年4月-2018年3月 北海道臨床衛生検査技師会学術部門委員 
2004年4月-現在     日本臨床細胞学会 理事
経歴 1983年 札幌医科大学附属病院検査部血液係
1985年 札幌医科大学附属病院病理部病理係
1987年 札幌医科大学附属病院検査部輸血係
1990年 札幌医科大学附属病院病理部病理係
2010年 札幌医科大学附属病院病理部病理係長
研究テーマと概要 【テーマ】
がん免疫(乳がんにおける癌免疫の解析)

【概要】
乳がんにおける各サブタイプの免疫病理形質を分類し、免疫療法の感受性について解析する。

主な研究業績

タイトル 出典(雑誌名) 巻号・ページ・発行年 単著・共著
【総説】
GIST病理診断標準化のための免疫染色 検査と技術(医学書院) 2010; 38: 426-428 共著
迅速凍結標本作成法 検査と技術(医学書院) 2003,31:1285-1291. 共著
迅速診断の標本作成に最良な固定液の選定 臨床検査 (医学書院) 2002,45:77-81 単著
非ホルマリン系固定液NoToXの使用経験 病理技術 1994,54:12-1 共著
抗血小板抗体の定量性測定法の試み-FCM法を用いて- 現代医療(現代医療社) 1990,22:125-130 単著
β―グルクロニダーゼ染色 染色法のすべて(医歯薬出版) 1984,84:145-147 共著
【原著論文】
Immunohistological analysis of pancreatic carcinoma after vaccination withsurvivin 2B peptide : Analysis of an autopsy series. Cancer Sci. 110(8):2386-2395.2019 共著
Randomized phase II trial of surviving 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarsinoma. Cancer Sci. 2378-2385.2019 共著
Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6cases of clear cellsarcoma -like gastrointestineal tumor Diagn Pathol 13!1):73.20q8 共著
コントロールの設定 検査と技術(医学書院) Vol.46 No.9 1054-1061, 2018 共著
Diagnostic utility of automated SureFISH (Dako Omnis) in the diagnosis of musculoskeletal translocation-related sarcomas. Pathol Int 67: 510-513, 201 共著
NUTM2A-CIC fusion small round cell sarcoma: A genetically distinct variant of CIC-rearranged sarcoma. Hum Pathol. 65: 225-230, 2017 共著
乳腺・甲状腺穿刺吸引細胞診におけるLBCへの応用 北海道臨床細胞学会会 25: 10-14,2016 単著
Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy. Clin Cancer Res 22: 3298-3309, 2016 共著
Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy. Oncotarget 7: 11223-112237, 2016 共著
Diagnostic use of fluorescence in situ hybridization in expert review in a phase 2 study of trabectedin monotherapy in patients with advanced, translocation-related sarcoma. Diagn Pathol 11: 37, 2016 共著
Diagnostic utility of FOSB immunohistochemistry in pseudomyogenic hemangioendothelioma and its histological mimics. Diagn Pathol Diagn Pathol 11: 75, 2016 共著
Phase I Clinical Study of Survivin-Derived Peptide Vaccine for Patients with Advanced Gastrointestinal Cancers. J Cancer Clin Res Vol.46 No.9 1054-1061, 2018 共著
成人の後腹膜に発生した多形型横紋筋肉腫の一例 北海道臨床細胞学会会報 24: 36-39,2015 共著
Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol 45(7):2028-41. 2015 共著
Smac13-Tat Fusion Peptide Induces Cell Death and Sensitizes HeLa Cells to Chemotherapeutic Drugs. Int J Cancer Clin Res 2:1,2015 共著
Expression of hepatocyte growth factor in prostate cancer may indicate a biochemical recurrence after radical prostatectomy. Anticancer Res 35: 413-418, 2015 共著
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. Lab Invest. 94(12):1355-69. 2014 共著
Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody. J Biol Chem 289: 22035-22047, 2014 共著
A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma. Am J Surg Pathol 38: 1571-1576, 2014 共著
後腹膜神経内分泌腫瘍の一例 日臨細胞北海道会報 22: 38-41,2013 共著
Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells. PLoS One 8: e69095, 2013 共著
High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma. PLoS One 8: e84187, 2013 共著
Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract. Mod Pathol 26: 117-124, 2013 共著
Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma. Virchows Arch 462: 101-107, 2013 共著
Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor. Cancer Sci 104: 431-436, 2013 共著
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. PLoS One 8: e65158, 2013 共著
Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication. Exp Cell Res 319: 2617-2626, 2013 共著
Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells. Pathol Int 63: 391-397, 2013 共著
Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population. PLoS One 8: e68187, 2013 共著
Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor. Hum Pathol 44: 1271-1277, 2013 共著
Rapid on-site evaluation by endosonographer during endoscopic ultrasound-guided fine needle aspiration for pancreatic solid masses. J Gastroenterol Hepatol 28: 656-663, 2013 共著
Validity and reproducibility of Ki-67 assessment in gastrointestinal stromal tumors and leiomyosarcomas. Pathol Int 63: 102-107, 2013 共著
DNA methyltransferase 1 is essential for initiation of the colon cancers. Exp Mol Pathol 94: 322-329, 2013 共著
Expression and function of FERMT genes in colon carcinoma cells. Anticancer Res 33: 167-173, 2013 共著
頭蓋底部に発生した脊索腫の2例 日臨細胞北海道会報 21: 60-65,2012 共著
セルブロックによって悪性中皮腫との鑑別が可能となった肺腺癌の1例 日臨細胞北海道会報 21: 43-47,2012 共著
High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis. Pathol Int 62: 684-689, 2012 共著
HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells. Cancer Res 72: 2844-2854, 2012 共著
Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues. Pathol Int 62: 303-308, 2012 共著
TFE3関連融合遺伝子形成を伴った若年性腎癌の1例 日臨細胞北海道会報 20: 43-47,2011 共著
SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity. Lab Invest 91: 1796-1804, 2011 共著
Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrentoral cancer. Cancer Sci 102: 324-329, 2011 共著
Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am J Pathol 178: 1805-1813, 2011 共著
The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. Exp Mol Pathol 90: 55-60, 2011 共著
腺癌との鑑別が困難であったgoblet cell carcinoidの一例 日臨細胞北海道会報 2010; 19: 26-29 共著
Use of tissue microarrays and immunohistochemistry to standardize the diagnosis of gastrointestinal stromal tumors. Pathol Int 60: 707-713, 2010 共著
北海道での細胞診プレパラートサーベイ「第15回」について 日臨細胞北海道会報 18: 47-57,2009 共著
乳腺腺様嚢胞癌(adenoid cystic carcinoma)の1例 日臨細胞北海道会報 18: 43-46, 2009 共著
Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. J Immunother 32: 474-485, 2009 共著
Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4. Cancer Sci 100: 1485-1493, 2009. 共著
乳癌の免疫逃避とそのメカニズムの解析 医学検査 57(4) : 779、2008 単著
Identification of an immunogenic CTL epitope of HIFPH3 for immunotherapy of renal cell carcinoma. Clin Cancer Res 14: 6916-6923, 2008 共著
Clinical and Immunological Evaluation of Anti-apoptosis Protein, Survivin-derived Peptide Vaccine in Phase I Clinical Study for Patients with Advanced or Recurrent Breast Cancer. J. Translational Med. 6: 24, 10 May, 2008 共著
The enhanced expression of the matrix metalloproteinase 9 in nasal NK/T-cell lymphoma. BMC Cancer 8: 45, 2008 共著
肝膿瘍液中に異型細胞を認めた、後腹膜脱分化型脂肪肉腫の一例 日臨細胞北海道会報 16: 44-47, 2007 共著
Down-regulation of HLA class I antigen is an independent prognostic factor for clear cell renal cell carcinoma. J Urol 177: 1269-1272, 2007 共著
Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition. J Urol 178: 692-696, 2007 共著
Expression of livin in renal cell carcinoma and detection of anti-livin autoantibody in patients. Urology 70: 38-42, 2007. 共著
Expression and antigenicity of surviving, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy. Urology 67: 955-959, 2006 共著
Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus calmette-guerin immunotherapy for bladder cancer. Clin Cancer Res 12: 4641-4644, 2006 共著
Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5. Cancer Sci 97: 1374-1380, 2006 共著
Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue. Histopathology 48: 157-161, 2006 共著
副腎に発生した神経節芽腫(Ganglioneuroblastoma)の1例 日臨細胞北海道会報 14: 20-23, 2005 共著
Survivin expression is regulated by coexpression of Human Epidermal Growth Factor Receptor 2 and Epidermal Growth Factor Receptor via Phosphatidylinositol 3-Kinase/AKT signaling pathway in breast cancer cells. Cancer Res 65: 11018-11025, 2005 共著
A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis. Cancer Res 65: 8706-8714, 2005 共著
Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. Hum Pathol 36: 234-241, 2005. 共著
A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis. Cancer Res 65: 8706-8714, 2005 共著
Survivin expression is regulated by co-expression of HER2 and EGFR via PI3K-AKT signaling pathway in breast cancer cells. Cancer Res 65: 11018-11025, 2005 共著
Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in Lung Cancer. Clin Cancer Res 11: 1000-1009, 2005 共著
A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. Clin Cancer Res 11: 1474-1482, 2005 共著
Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma. J Transl Med 3: 1, 2005 共著
乳腺invasive micropapillary carcinomaの1例 日本臨床細胞学会北海道支部会報 13: 27-30,2004 共著
耳下腺悪性筋上皮種の1例 日本臨床細胞学会北海道支部会報 13: 22-26,2004 共著
尿円柱の永久標本作成法 医学検査 53: 955-959.2004 共著
甲状腺の超音波像と病理組織診断の対比 医学検査 53: 267-271,2004 共著
尿細胞診に白血病細胞を認め腎転移が示唆された急性リンパ性白血病の1例 日本臨床細胞学会北海道支部会報 12: 39-42,2003 共著
Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein. Cell stress & chaperones. Cell stress & chaperones 64: 5442-5448,2004 共著
Phase I Clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer. Journal of Tanslational Medicine 2: 19,2004 共著
Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor. Cancer Res 64: 5442-5448, 2004 共著
Expression of matrix metalloproteinase 9 is a prognostic factor in patients with non-Hodgkin lymphoma. Cancer 100: 356-365,2004 共著
Localization and function in ER stress tolerance of ERdj3 molecule, a new member of HSP40 family protein. Cell Stress & Chaperones 9: 253-264, 2004 共著
Detection of anti-livin antibody in gastrointestinal cancer patients. Clinical Chemistry 49: 1206-1208, 2003 共著
乳腺invasive micropapillary carcinoma症例の検討 日本臨床外科学会誌 64: 2369-2374,2003 共著
嚢胞形成を伴う腎オンコサイトーマの一例 日本臨床細胞学会北海道支部会報 11: 53-56,2002 共著
High Throughputな迅速凍結標本の作製 医学検査 51: 1121-1126,2002 共著
髄液中に出現したT/NK cell Lymphomaの一例 日本臨床細胞学会北海道支部会報 10: 57-60,2001 共著
穿刺吸引細胞診で推定し得た同時性両側原発性乳癌の一例 日本臨床細胞学会北海道支部会報 9: 38-41,2000 共著
尿中に出現した腎細胞癌の一例 日本臨床細胞学会北海道支部会報 8: 1-44,1999 共著
A monoclonal antibody, 3G12, reacts with a novel surface molecule Hal-1, with high expression in CD30-positive an aplastic large cell lymphomas. Brit.J.Hematol 106: 55-63,1999 共著
悪性中皮腫の免疫組織学的診断におけるカルレチニンの有用性について 病理技術 58: 9-14,1998 共著
胞巣状軟部肉腫(alveolar soft part sarcoma) 日本臨床細胞学会北海道支部会報 7: 59-63,1998 共著
ヘリコバクターピロリに対する染色法(McMullen変法)を用いた簡便なレジオネラ菌の病理組織染色法 医学検査 46: 1496-1498,1998 共著
Comparative cytology of stromal tumors of the gastrointestinal tract : A case report. Tumor Reseach 32: 41-48,1998 共著
Cytology of malignant endocrine tumor of the pancreas : A case report. Tumor Reseach 32: 49-55,1998 共著
迅速捺印細胞診で診断し得た結膜悪性黒色腫の一例 日本臨床細胞学会北海道支部会報 5:55-59,1996 共著
Helicobacter pylori(HP)の組織学的検査法 改良Genta法の実際と染色性 医学検査 44: 1552-1555,1995 共著
Immunohistochemical detection of estrogen receptor in invasive human breast cancer: Correlation with heat shock protein, pS2 and oncogene products. Oncology 52: 371-375,1995 共著
二重染色 EPOS文献集 54:9-10,1995 共著
三洋化成CA19-9試薬の臨床的評価 医学検査 42:973-978,1993 共著
An Antiproliferative Monoclomnal Antibody,4F9,Reacts with aSubset of Human CD45 Molecules. Tumor Research 27:37-49,1993 共著
Sysmex PAMIA-100における血中CA19-9測定の評価-第2報- 臨床検査機器・試薬 14:307-313,1991 共著
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